Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer's disease

Abstract Introduction Clinical trials for sporadic Alzheimer's disease generally use mixed models for repeated measures (MMRM) or, to a lesser degree, constrained longitudinal data analysis models (cLDA) as the analysis model with time since baseline as a categorical variable. Inferences using MMRM/...

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Principais autores:	Guoqiao Wang, Lei Liu, Yan Li, Andrew J. Aschenbrenner, Randall J. Bateman, Paul Delmar, Lon S. Schneider, Richard E. Kennedy, Gary R. Cutter, Chengjie Xiong
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2022-01-01
Series:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Assuntos:	Alzheimer's disease proportional constrained longitudinal data analysis model (PcLDA) MMRM proportional MMRM (pMMRM) proportional treatment effect
Acceso en liña:	https://doi.org/10.1002/trc2.12286
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