Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia

IntroductionEndotoxemia, marked by the presence of bacterial lipopolysaccharide (LPS) in the bloodstream, induces acute inflammation and is implicated in both mortality and chronic disease across species. LPS stimulates lipolysis and activates cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome...

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Hauptverfasser:	Madison N. Myers, Miguel Chirivi, Jose M. dos Santos Neto, Jair Parales-Girón, Lynn C. Worden, Adam L. Lock, G. Andres Contreras
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-06-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	endotoxemia oxylipins lipid-based mediators of inflammation dairy cows adipose tissue
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595888/full
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