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Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines

Abstract Background Cyclooxygenase-2 (COX-2), an inflammation-associated enzyme, has been implicated in tumorigenesis and progression of glioblastoma (GBM). The poor survival of GBM was mainly associated with the presence of glioma stem cells (GSC) and the markedly inflammatory microenvironment. To...

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Principais autores: Paola Palumbo, Francesca Lombardi, Francesca Rosaria Augello, Ilaria Giusti, Vincenza Dolo, Pietro Leocata, Maria Grazia Cifone, Benedetta Cinque
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-05-01
Serier:Cancer Cell International
Fag:
Glioblastoma
U87MG
T98G
Glioma stem cells
Inflammation
COX-2
Online adgang:http://link.springer.com/article/10.1186/s12935-020-01250-7
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