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TRIM21 and Fc-engineered antibodies: decoding its complex antibody binding mode with implications for viral neutralization

TRIM21 is a pivotal effector in the immune system, orchestrating antibody-mediated responses and modulating immune signaling. In this comprehensive study, we focus on the interaction of TRIM21 with Fc engineered antibodies and subsequent implications for viral neutralization. Through a series of ana...

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Автори: Johannes Reusch, Linda Elise Franken, Jakob Then, Philippe Ringler, Joachim Butzer, Thomas Juroschek, Christian Klein, Tilman Schlothauer, Laurent Larivière
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2024-06-01
Серія:Frontiers in Immunology
Предмети:
TRIM21
therapeutic IgG
antibody Fc mutants
antibody mediated viral neutralization
binding kinetics
affinity
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1401471/full
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