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Impact of rAAV-shRNA treatment targeting mechanosensitive Ilk1 and Fermt2 in a mouse model of sepsis-induced muscle weakness.

<h4>Introduction</h4>Intensive-care-unit-acquired-muscle-weakness is a debilitating complication of sepsis, characterized by loss of muscle mass and functionality. Immobilization is an important trigger, but the role of disturbed mechanical signaling is incompletely understood. In health, the integr...

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Главные авторы: Alexander Pacolet, Inge Derese, Lies Pauwels, Sarah Vander Perre, Maxime Smits, Chris Van den Haute, Sarah Derde, Katrien Koppo, Rik Gijsbers, Lies Langouche
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2025-01-01
Серии:PLoS ONE
Online-ссылка:https://doi.org/10.1371/journal.pone.0338338
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