Impact of rAAV-shRNA treatment targeting mechanosensitive Ilk1 and Fermt2 in a mouse model of sepsis-induced muscle weakness.

<h4>Introduction</h4>Intensive-care-unit-acquired-muscle-weakness is a debilitating complication of sepsis, characterized by loss of muscle mass and functionality. Immobilization is an important trigger, but the role of disturbed mechanical signaling is incompletely understood. In health, the integr...

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Hlavní autoři:	Alexander Pacolet, Inge Derese, Lies Pauwels, Sarah Vander Perre, Maxime Smits, Chris Van den Haute, Sarah Derde, Katrien Koppo, Rik Gijsbers, Lies Langouche
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2025-01-01
Edice:	PLoS ONE
On-line přístup:	https://doi.org/10.1371/journal.pone.0338338
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