Temporospatial heterogeneity of acquired resistance mechanisms in EGFR-mutant lung adenocarcinoma: A case of concurrent EGFRT790M mutation and small cell transformation

Activating epidermal growth factor receptor gene mutations (EGFRm) are relatively common in non-small cell lung cancer (NSCLC) and are predictive of superior outcomes with EGFR tyrosine kinase inhibitors (TKIs). Eventually, acquired genetic or phenotypic resistance overcomes EGFR TKI therapy. Hetero...

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मुख्य लेखकों:	Daniel Johnathan Hughes, Gary JR Cook, Emma McLean, Daniel Smith, Juliet King, Athanasios Diamantopoulos, Aled Jones, Michael Neat, George Santis, James Spicer, Eleni Karapanagiotou, Alexandros Georgiou
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2021-12-01
श्रृंखला:	Current Problems in Cancer: Case Reports
विषय:	EGFR NSCLC T790M SCLC transformation Heterogeneity
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S2666621921000545
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