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A Recombinant Zika Virus Envelope Protein with Mutations in the Conserved Fusion Loop Leads to Reduced Antibody Cross-Reactivity upon Vaccination

Zika virus (ZIKV) is a zoonotic, human pathogenic, and mosquito-borne flavivirus. Its distribution is rapidly growing worldwide. Several attempts to develop vaccines for ZIKV are currently ongoing. Central to most vaccination approaches against flavivirus infections is the envelope (E) protein, whic...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Beatrice Sarah Berneck, Alexandra Rockstroh, Jasmin Fertey, Thomas Grunwald, Sebastian Ulbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-10-01
Schriftenreihe:Vaccines
Schlagworte:
Zika virus
E-protein
fusion loop
mutations
vaccine
dengue virus
Online-Zugang:https://www.mdpi.com/2076-393X/8/4/603
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