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Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration. Although tendon stem/progenitor cells (TSPCs) are pivotal for tendon engineering, achieving microstructure and functional regeneration remains challenging. Organo...

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Principais autores: Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-03-01
Serier:Advanced Science
Fag:
ALKBH5
mRNA demethylation
tendon organoids
tendon regeneration
tendon stem/progenitor cells
Online adgang:https://doi.org/10.1002/advs.202508376
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