Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer

Abstract In epithelial ovarian cancer (EOC), platinum resistance, potentially mediated by cancer stem cells (CSCs), often leads to relapse and treatment failure. Here, the role of spindle pole body component 25 (SPC25) as a key determinant promoting stemness and platinum resistance in EOC cells, wit...

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Autors principals:	Xingyu Jiang, Muwen Yang, Weijing Zhang, Dongni Shi, Yue Li, Lixin He, Shumei Huang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Yibing Pan, Pinwei Deng, Rui Wang, Ying Ouyang, Xiangfu Chen, Jun Li, Zheng Li, Hequn Zou, Yanna Zhang, Libing Song
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2024-12-01
Col·lecció:	Advanced Science
Matèries:	cancer stem cell cell‐penetrating peptide epithelial ovarian cancer phosphorylation platinum resistance protein‐protein interaction
Accés en línia:	https://doi.org/10.1002/advs.202406688
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