Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis

Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor (GLP-1R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver f...

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Principais autores:	Nazi Song, Hongjiao Xu, Jiahua Liu, Qian Zhao, Hui Chen, Zhibin Yan, Runling Yang, Zhiteng Luo, Qi Liu, Jianmei Ouyang, Shuohan Wu, Suijia Luo, Shuyin Ye, Runfeng Lin, Xi Sun, Junqiu Xie, Tian Lan, Zhongdao Wu, Rui Wang, Xianxing Jiang
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2022-05-01
叢編:	Acta Pharmaceutica Sinica B
主題:	GLP-1R GCGR Liver fibrosis Inflammation Apoptosis Candidate peptides
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2211383521004883
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