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L-asparaginase from the novel Fusarium falciforme AUMC 16563: extraction, purification, characterization, and cytotoxic effects on PC-3, HePG-2, HCT-116, and MCF-7 cell lines

Abstract Background L-asparaginase has been a widely employed as antitumor enzyme for the treatment of acute lymphoblastic leukemia for almost three decades. The enzyme takes advantage of the inability of tumor cells to synthesize the L-asparagine and is killed by L‐asparagine deprivation. Despite t...

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Hoofdauteurs: Abdullah Abobakr Saleh, Hamdy M. El-Aref, Azza M. Ezzeldin, Rania M. Ewida, Osama A. M. Al-Bedak
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2025-03-01
Reeks:BMC Microbiology
Onderwerpen:
L-asparaginase
Fusarium falciforme
Optimization
Submerged fermentation
Cancer therapy
Cell lines
Online toegang:https://doi.org/10.1186/s12866-025-03833-8
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