Application of FRET- and BRET-based live-cell biosensors in deorphanization and ligand discovery studies on orphan G protein-coupled receptors

Bioluminescence- and fluorescence-based resonance energy transfer assays have gained considerable attention in pharmacological research as high-throughput scalable tools applicable to drug discovery. To this end, G protein-coupled receptors represent the biggest target class for marketed drugs, and...

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Autors principals:	Joanna J. Sajkowska, Choi Har Tsang, Paweł Kozielewicz
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	SLAS Discovery
Matèries:	BRET FRET Live-cell assays Orphan G protein-coupled receptors Deorphanization Ligand discovery
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2472555224000364
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