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Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

ABSTRACT The RAS–RAF–MEK–ERK signaling cascade is a central component of the mitogen‐activated protein kinase (MAPK) pathway, regulating cell proliferation, differentiation, and survival, and is frequently dysregulated in cancer. Despite extensive biochemical characterization, direct observation of...

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Principais autores: Jeong‐Min Go, Dahee Lee, Minji Kim, Kiseok Han, Gyuho Choi, ChanHui Song, Sanghyun Ahn, Yerim Lee, Jinyoung Lee, Yingxiao Wang, Jung‐Soo Suh, Hwayoung Yun, Tae‐Jin Kim
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-04-01
Serier:Advanced Science
Fag:
biosensor
BRET
FRET
KRAS
live‐cell imaging
RAF
Online adgang:https://doi.org/10.1002/advs.202515654
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