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Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection. How this function is regulated locally and across the cell cycle to channel repair reactions toward non-homologous end j...

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Autori principali: Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017-05-01
Serie:Cell Reports
Soggetti:
53BP1
NHEJ
HDR
HR
H4K20
histone methylation
chromatin
DNA repair
DSB repair pathway choice
genome stability
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124717306411
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