Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection. How this function is regulated locally and across the cell cycle to channel repair reactions toward non-homologous end j...

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Detalhes bibliográficos

Principais autores:	Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-05-01
Colecção:	Cell Reports
Assuntos:	53BP1 NHEJ HDR HR H4K20 histone methylation chromatin DNA repair DSB repair pathway choice genome stability
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124717306411
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