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High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition

Chemical inhibition of the human ether-a -go-go-related gene (hERG) potassium channel leads to a prolonged QT interval that can contribute to severe cardiotoxicity. The adverse effects of hERG inhibition are one of the principal causes of drug attrition in clinical and pre-clinical development. Prel...

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Principais autores: Shagun Krishna, Alexandre Borrel, Ruili Huang, Jinghua Zhao, Menghang Xia, Nicole Kleinstreuer
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-01-01
coleção:Biology
Assuntos:
cardiovascular
hERG
Tox21 high-throughput screening
environmental chemicals
in silico modeling
QSAR models
Acesso em linha:https://www.mdpi.com/2079-7737/11/2/209
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