APOE ε4-associated hippocampal atrophy trajectories across the Alzheimer's disease continuum: a systematic review, meta-analysis, and longitudinal validation

BackgroundPredicting patient-specific neurodegenerative trajectories is essential for targeted interventions in Alzheimer's disease. Although the APOE-ε4 allele is the predominant genetic risk factor for hippocampal atrophy, whether its structural impact reflects a static developmental phenotype or...

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Bibliografische Detailangaben

Hauptverfasser:	Minnuo Cai, Hang Lei, Yuetong Zhang, Jiaxiang Zou, Wanjing Cao, Yiquan Wang, Kai Wei
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-07-01
Schriftenreihe:	Frontiers in Aging Neuroscience
Schlagworte:	AD spectrum amyloid interaction APOE-ε4 hippocampal volume systematic review
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fnagi.2026.1847611/full
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