Evolution of the p53-MDM2 pathway

Abstract Background The p53 signalling pathway, which controls cell fate, has been extensively studied due to its prominent role in tumor development. The pathway includes the tumor supressor protein p53, its vertebrate paralogs p63 and p73, and their negative regulators MDM2 and MDM4. The p53/p63/p...

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Principais autores:	Emma Åberg, Fulvio Saccoccia, Manfred Grabherr, Wai Ying Josefin Ore, Per Jemth, Greta Hultqvist
格式:	Artigo
语言:	Inglês
出版:	BMC 2017-08-01
丛编:	BMC Evolutionary Biology
主题:	p53 MDM Co-evolution Phylogeny
在线阅读:	http://link.springer.com/article/10.1186/s12862-017-1023-y
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