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Resolvin D1 alleviates liver inflammation and fibrosis through SIRT1-mediated NF-κB and TGF-β1/Smads pathways

Abstract Objective Resolvin D1 (RvD1) is lipid mediator converted from docosahexaenoic acid (DHA) and has multiple pharmacological properties. Recently, it has been reported that RvD1 alleviates tissue fibrosis, including renal and pulmonary fibrosis in animal models. Here, we investigate the effect...

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Principais autores: Jiahuan Li, Lingfeng Zhao, Yuwen Xi, Xiaoling Deng
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-03-01
Series:Journal of Inflammation
Assuntos:
Resolvin D1
Liver fibrosis
Inflammation
HSC activation
SIRT1
NF-κB
Acceso en liña:https://doi.org/10.1186/s12950-026-00492-y
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