TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway

Introductions: Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited. The transient receptor potential melastatin 2 (TRPM2) is involved in a range of disease processes, yet its role in OA remains unclear. Objectives...

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Auteurs principaux:	Kai Sun, Xiong Zhang, Liangcai Hou, Fan Lu, Haigang Liu, Zehang Zheng, Zhou Guo, Jingting Xu, Zhaoxuan Ruan, Yanjun Hou, Junchen He, Fengjing Guo, Kaixiang Yang
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2025-09-01
Collection:	Journal of Advanced Research
Sujets:	Osteoarthritis Chondrocyte TRPM2 Calcium ions NF-κB
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2090123224004995
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