Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths

B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve, e.g., base substitution, codon insertion and deletion, often in association with an isotype switch. Inve...

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Auteurs principaux:	Ufuk Kirik, Helena Persson, Fredrik Levander, Lennart Greiff, Mats Ohlin
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2017-11-01
Collection:	Frontiers in Immunology
Sujets:	antibody germline gene antibody sequence somatic hypermutation immunoglobulin insertion and deletion substitution
Accès en ligne:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01433/full
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