Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuriaResearch in context

Summary: Background: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proliferator-activated receptor ɣ (PPARɣ) agonists can...

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Detalhes bibliográficos

Principais autores:	Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H. van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A.A.M. Kamps, Daniël H. van Raalte, Rutger W. van der Meer, Hildo J. Lamb, Jan-Luuk Hillebrands, Ton J. Rabelink, Marissa L. Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-04-01
coleção:	EBioMedicine
Assuntos:	Peroxisome proliferator-activated receptor ɣ Heparanase Proteinuria Thiazolidinediones Glomerular endothelial cells Podocytes
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396423000713
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