Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuriaResearch in context

Summary: Background: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proliferator-activated receptor ɣ (PPARɣ) agonists can...

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主要な著者:	Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H. van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A.A.M. Kamps, Daniël H. van Raalte, Rutger W. van der Meer, Hildo J. Lamb, Jan-Luuk Hillebrands, Ton J. Rabelink, Marissa L. Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2023-04-01
シリーズ:	EBioMedicine
主題:	Peroxisome proliferator-activated receptor ɣ Heparanase Proteinuria Thiazolidinediones Glomerular endothelial cells Podocytes
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2352396423000713
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