Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo
Abstract Background Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presentation of the disease includes fibrosis, cirrhosis and liver failure. How...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2020-09-01
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| Col·lecció: | Cell Communication and Signaling |
| Matèries: | |
| Accés en línia: | http://link.springer.com/article/10.1186/s12964-020-00648-0 |
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