Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo

Abstract Background Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presentation of the disease includes fibrosis, cirrhosis and liver failure. How...

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Hlavní autoři:	Nazli Khodayari, Regina Oshins, L. Shannon Holliday, Virginia Clark, Qiang Xiao, George Marek, Borna Mehrad, Mark Brantly
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-09-01
Edice:	Cell Communication and Signaling
Témata:	Alpha-1 antitrypsin Extracellular vesicles Cytokine miRNA Liver fibrosis
On-line přístup:	http://link.springer.com/article/10.1186/s12964-020-00648-0
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