Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status

Abstract Background Head and neck cancers (HNC) represent an extremely heterogeneous group of diseases with a poorly predictable therapy outcome. Patient-derived tumor organoids (PDTO) offer enormous potential for individualized therapy testing and a better mechanistic understanding of the main HNC...

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Библиографические подробности

Главные авторы:	Christian Issing, Constantin Menche, Mara Romero Richter, Mohammed H. Mosa, Jens von der Grün, Maximilian Fleischmann, Philipp Thoenissen, Ria Winkelmann, Tahmineh Darvishi, Andreas G. Loth, Shahram Ghanaati, Franz Rödel, Peter J. Wild, Christian H. Brandts, Timo Stöver, Henner F. Farin
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-03-01
Серии:	Journal of Experimental & Clinical Cancer Research
Предметы:	Head and neck squamous cell carcinoma Tumor organoid biobank Preclinical model In vitro therapy testing Radioresistance Genetic editing
Online-ссылка:	https://doi.org/10.1186/s13046-025-03345-3
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