Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status

Abstract Background Head and neck cancers (HNC) represent an extremely heterogeneous group of diseases with a poorly predictable therapy outcome. Patient-derived tumor organoids (PDTO) offer enormous potential for individualized therapy testing and a better mechanistic understanding of the main HNC...

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主要な著者:	Christian Issing, Constantin Menche, Mara Romero Richter, Mohammed H. Mosa, Jens von der Grün, Maximilian Fleischmann, Philipp Thoenissen, Ria Winkelmann, Tahmineh Darvishi, Andreas G. Loth, Shahram Ghanaati, Franz Rödel, Peter J. Wild, Christian H. Brandts, Timo Stöver, Henner F. Farin
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2025-03-01
シリーズ:	Journal of Experimental & Clinical Cancer Research
主題:	Head and neck squamous cell carcinoma Tumor organoid biobank Preclinical model In vitro therapy testing Radioresistance Genetic editing
オンライン･アクセス:	https://doi.org/10.1186/s13046-025-03345-3
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