Application of Box-Behnken experimental design and response surface methodology for selecting the optimum RP-HPLC conditions for the simultaneous determination of methocarbamol, indomethacin and betamethasone in their pharmaceutical dosage form

Abstract An isocratic RP-HPLC method has been developed for the separation and determination of methocarbamol (MTL), indomethacin (IND), and betamethasone (BET) in combined dosage form using an Inertsil ODS-3v C18 (250 × 4.6 mm, 5 μm) column with UV- detection at 235 nm. Experimental design using Bo...

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Principais autores:	Ehab F. Elkady, Marwa A. Fouad, Ayoub N. Mozayad
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-12-01
coleção:	BMC Chemistry
Assuntos:	Methocarbamol Indomethacin Betamethasone Box-Behnken design RP-HPLC Response surface methodology
Acesso em linha:	https://doi.org/10.1186/s13065-022-00908-9
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