A quality by design (QbD) case study on enteric-coated pellets: Screening of critical variables and establishment of design space at laboratory scale

The study aims to prepare naproxen enteric-coated pellets (NAP-ECPs) by fluid-bed coating using QbD principle. Risk assessment was firstly performed by using failure mode and effect analysis (FMEA) methodology. A Plackett–Burman design was then used for assessment of the most important variables aff...

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Autores principales:	Shuling Kan, Jing Lu, Jianping Liu, Junlin Wang, Yi Zhao
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2014-10-01
Colección:	Asian Journal of Pharmaceutical Sciences
Materias:	Fluid-bed coating Plackett–Burman design Box–Behnken design Naproxen Quality by design
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1818087614000609
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