Structural Basis of Chemokine CXCL8 Monomer and Dimer Binding to Chondroitin Sulfate: Insights into Specificity and Plasticity

Chemokines play a central role in orchestrating neutrophil recruitment from the bloodstream and determining their effector functions at sites of infection. Chemokine activity is determined by three key properties: reversible monomer–dimer equilibrium, binding to glycosaminoglycans (GAGs), and signal...

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Hlavní autoři:	Bryon P. Mahler, Balaji Nagarajan, Nehru Viji Sankaranarayanan, Prem Raj B. Joseph, Umesh R. Desai, Krishna Rajarathnam
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2026-01-01
Edice:	Biomolecules
Témata:	chemokine CXCL8 interleukin-8 glycosaminoglycan chondroitin sulfate heparan sulfate
On-line přístup:	https://www.mdpi.com/2218-273X/16/1/124
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!