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Structural Basis of Chemokine CXCL8 Monomer and Dimer Binding to Chondroitin Sulfate: Insights into Specificity and Plasticity

Chemokines play a central role in orchestrating neutrophil recruitment from the bloodstream and determining their effector functions at sites of infection. Chemokine activity is determined by three key properties: reversible monomer–dimer equilibrium, binding to glycosaminoglycans (GAGs), and signal...

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Principais autores: Bryon P. Mahler, Balaji Nagarajan, Nehru Viji Sankaranarayanan, Prem Raj B. Joseph, Umesh R. Desai, Krishna Rajarathnam
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-01-01
Serier:Biomolecules
Fag:
chemokine
CXCL8
interleukin-8
glycosaminoglycan
chondroitin sulfate
heparan sulfate
Online adgang:https://www.mdpi.com/2218-273X/16/1/124
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