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SGK1 triggers cartilage degradation in TMJOA via FoxO1/autophagy

Abstract Background Temporomandibular joint osteoarthritis (TMJOA) is a prevalent inflammatory disease with unclear pathogenesis. Serum and glucocorticoid-inducible kinase 1 (SGK1) has been implicated in osteoarthritis-related cartilage degeneration. This study investigated the role of SGK1 in a mou...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Hongyao Tang, Chuan Ma, Mengchen Xu, Gaoyi Wu, Na Li, Lei Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-12-01
Schriftenreihe:Arthritis Research & Therapy
Schlagworte:
Temporomandibular joint
Condylar cartilage
Chondrocyte
Extracellular matrix
Catabolism
Anabolism
Online-Zugang:https://doi.org/10.1186/s13075-025-03690-w
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