GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

Abstract Background Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) have not been reported in detail. Methods The expression of GPX4 in EC tissues was determined by TCGA databases, qRT-PCR, Wester...

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Principais autores:	Sitian Wei, Zhicheng Yu, Rui Shi, Lanfen An, Qi Zhang, Qian Zhang, Tangansu Zhang, Jun Zhang, Hongbo Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2022-08-01
Series:	BMC Cancer
Assuntos:	Endometrial carcinoma GPX4 ELK1 Ferroptosis Transcriptional activation
Acceso en liña:	https://doi.org/10.1186/s12885-022-09986-3
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