GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

Abstract Background Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) have not been reported in detail. Methods The expression of GPX4 in EC tissues was determined by TCGA databases, qRT-PCR, Wester...

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主要な著者:	Sitian Wei, Zhicheng Yu, Rui Shi, Lanfen An, Qi Zhang, Qian Zhang, Tangansu Zhang, Jun Zhang, Hongbo Wang
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2022-08-01
シリーズ:	BMC Cancer
主題:	Endometrial carcinoma GPX4 ELK1 Ferroptosis Transcriptional activation
オンライン･アクセス:	https://doi.org/10.1186/s12885-022-09986-3
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