Identification and validation of a tear fluid-derived protein biomarker signature in patients with amyotrophic lateral sclerosis

Abstract The diagnosis of Amyotrophic Lateral Sclerosis (ALS) remains challenging, particularly in early stages, where characteristic symptoms may be subtle and nonspecific. The development of disease-specific and clinically validated biomarkers is crucial to optimize diagnosis. Here, we explored te...

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Autori principali:	Lena-Sophie Scholl, Antonia F. Demleitner, Jenny Riedel, Seren Adachi, Lisa Neuenroth, Clara Meijs, Laura Tzeplaeff, Lucas Caldi Gomes, Ana Galhoz, Isabell Cordts, Christof Lenz, Michael Menden, Paul Lingor
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-09-01
Serie:	Acta Neuropathologica Communications
Soggetti:	Amyotrophic lateral sclerosis Biomarker Tear fluid Diagnosis Proteomics Neurodegeneration
Accesso online:	https://doi.org/10.1186/s40478-025-02109-6
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