The gut microbiota and plasma metabolites on functional dyspepsia: a study integrating Mendelian randomization and experimental validation

ObjectiveThis two-sample Mendelian randomization (MR) investigation aimed to explore how gut microbiota influences functional dyspepsia (FD) via plasma metabolites. The results were then confirmed in vivo.MethodsA GWAS of 7,738 people was used to generate genetic instruments for 412 gut microbiota c...

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Ngā kaituhi matua:	Xinxin Hu, Xueping Zhang, Chen Yang, Lei Chen, Ruirong Yang, Chengxiang Wang, Suowei Wu, Lixin Ma, Wenqi Jiang, Pumin Deng, Xiaolan Su, Wei Wei
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2026-03-01
Rangatū:	Frontiers in Medicine
Ngā marau:	alpha-hydroxyisocaproate functional dyspepsia kynurenate Mendelian randomization p_ Actinobacteria
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fmed.2026.1793831/full
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