Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase

The mechanism(s) of volatile anesthetics (VA) are poorly understood. We used high resolution NMR spectroscopy to determine the structure of the halothane/calmodulin([Ca2+]4-CaM) complex, and found that halothane molecules bind in the druggable sites. We then examined whether VA binding to d...

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Autores principales:	Juranić Nenad O., Jones Keith A., Penheiter Alan R., Hock Thomas J., Streiff John H.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Serbian Chemical Society 2013-01-01
Colección:	Journal of the Serbian Chemical Society
Materias:	Volatile anesthetic calmodulin CaM halothane drugs protein structure
Acceso en línea:	http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391300090J.pdf
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