Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation

ABSTRACT Nontuberculous mycobacteria (NTM) can form biofilms during human infection and in household plumbing systems, so understanding biofilm regulation could help us better treat and prevent NTM infections. Glucose drives NTM aggregation in vitro, and ammonium inhibits it, but the regulatory syst...

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Detalhes bibliográficos

Principais autores:	Elizabeth Varner, Mitchell Meyer, Jocelyn Whalen, Yu-Hao Wang, Carlos Rodriguez, Ifra Malik, Steven J. Mullet, Stacy L. Gelhaus, William H. DePas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-11-01
coleção:	Journal of Bacteriology
Assuntos:	biofilms nitrogen metabolism nontuberculous mycobacteria purine metabolism Flux-dependent sensors
Acesso em linha:	https://journals.asm.org/doi/10.1128/jb.00252-25
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