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Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation

ABSTRACT Nontuberculous mycobacteria (NTM) can form biofilms during human infection and in household plumbing systems, so understanding biofilm regulation could help us better treat and prevent NTM infections. Glucose drives NTM aggregation in vitro, and ammonium inhibits it, but the regulatory syst...

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Principais autores: Elizabeth Varner, Mitchell Meyer, Jocelyn Whalen, Yu-Hao Wang, Carlos Rodriguez, Ifra Malik, Steven J. Mullet, Stacy L. Gelhaus, William H. DePas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-11-01
Serier:Journal of Bacteriology
Fag:
biofilms
nitrogen metabolism
nontuberculous mycobacteria
purine metabolism
Flux-dependent sensors
Online adgang:https://journals.asm.org/doi/10.1128/jb.00252-25
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