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Engineering PD-1-targeted small protein variants for in vitro diagnostics and in vivo PET imaging

Abstract Background Programmed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell lung cancer (NSCLC), the sensitivity to treatment with anti-PD-1 therapeutics, and its efficacy, mostly correlated with the increase of tumo...

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Principais autores: Joanna Maria Mierzwicka, Hana Petroková, Leona Rašková Kafková, Petr Kosztyu, Jiří Černý, Milan Kuchař, Miloš Petřík, Kateřina Bendová, Kristýna Krasulová, Yaroslava Groza, Lucie Vaňková, Shiv Bharadwaj, Natalya Panova, Michal Křupka, Jozef Škarda, Milan Raška, Petr Malý
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-05-01
Serier:Journal of Translational Medicine
Fag:
Immune checkpoint
Programmed cell death 1
Non-small cell lung cancer
Cancer diagnostic
Combinatorial library
Protein engineering
Online adgang:https://doi.org/10.1186/s12967-024-05210-x
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