C3G promotes bone marrow adipocyte expansion and hematopoietic regeneration after myeloablation by enhancing megakaryocyte niche function

Abstract C3G, a Rap1 GEF, promotes megakaryopoiesis and platelet function. Using transgenic and knock-out mouse models targeting C3G in megakaryocytes, we investigated whether C3G also affects the niche function of megakaryocytes during bone marrow (BM) recovery after myeloablation induced by 5-fluo...

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Autors principals:	Óscar Herranz, Pablo Berrocal, Carmen Sicilia-Navarro, Cristina Fernández-Infante, Luis Hernández-Cano, Almudena Porras, Carmen Guerrero
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-04-01
Col·lecció:	Journal of Hematology & Oncology
Matèries:	Rapgef1 Megakaryocyte Bone marrow niche Myeloablation Adipocyte Hematopoietic stem cell
Accés en línia:	https://doi.org/10.1186/s13045-025-01687-1
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