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C3G promotes bone marrow adipocyte expansion and hematopoietic regeneration after myeloablation by enhancing megakaryocyte niche function

Abstract C3G, a Rap1 GEF, promotes megakaryopoiesis and platelet function. Using transgenic and knock-out mouse models targeting C3G in megakaryocytes, we investigated whether C3G also affects the niche function of megakaryocytes during bone marrow (BM) recovery after myeloablation induced by 5-fluo...

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Principais autores: Óscar Herranz, Pablo Berrocal, Carmen Sicilia-Navarro, Cristina Fernández-Infante, Luis Hernández-Cano, Almudena Porras, Carmen Guerrero
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-04-01
Serier:Journal of Hematology & Oncology
Fag:
Rapgef1
Megakaryocyte
Bone marrow niche
Myeloablation
Adipocyte
Hematopoietic stem cell
Online adgang:https://doi.org/10.1186/s13045-025-01687-1
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