An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase ac...

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Bibliografische Detailangaben

Hauptverfasser:	Xiaoming Yi, Dennis M. White, Dara L. Aisner, Joseph A. Baur, Woodring E. Wright, Jerry W. Shay
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2000-09-01
Schriftenreihe:	Neoplasia: An International Journal for Oncology Research
Schlagworte:	human telomerase alternate splicing dominant-negative inhibitor telomere apoptosis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1476558600800135
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