C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response

Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA) formation. Here, we show that changes to the cytoskel...

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Detalhes bibliográficos

Principais autores:	Tomo Shiota, Riko Nagata, Sotaro Kikuchi, Hitoki Nanaura, Masaya Matsubayashi, Mari Nakanishi, Shinko Kobashigawa, Noriyoshi Isozumi, Takao Kiriyama, Kazuaki Nagayama, Kazuma Sugie, Yoshito Yamashiro, Eiichiro Mori
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-03-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	C9orf72 PR poly-dipeptides cytoskeleton Focal Adhesion (FA) actin
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2022.750829/full
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