Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria

Cystinuria is caused by mutations in heterodimeric amino acid transporter known as system b0,+. Here, authors discover that Ca2+ stabilizes the interface between two system b0,+ regulatory subunits rBAT, leading to super-dimerization of the b0,+AT–rBAT heterodimer, facilitating system b0,+ maturatio...

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Detalhes bibliográficos

Principais autores:	Yongchan Lee, Pattama Wiriyasermkul, Pornparn Kongpracha, Satomi Moriyama, Deryck J. Mills, Werner Kühlbrandt, Shushi Nagamori
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2022-05-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-022-30293-9
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