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Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity

Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that sequestration of FA is due to the enrichment of caveolin in the cytosolic leaflet and its ability to facilitate the formation of lipid rafts...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Jeffrey R. Simard, Tova Meshulam, Biju K. Pillai, Michael T. Kirber, Kellen Brunaldi, Su Xu, Paul F. Pilch, James A. Hamilton
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2010-05-01
Rangatū:Journal of Lipid Research
Ngā marau:
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S0022227520410466
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