Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity

Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that sequestration of FA is due to the enrichment of caveolin in the cytosolic leaflet and its ability to facilitate the formation of lipid rafts...

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Bibliografische gegevens

Hoofdauteurs:	Jeffrey R. Simard, Tova Meshulam, Biju K. Pillai, Michael T. Kirber, Kellen Brunaldi, Su Xu, Paul F. Pilch, James A. Hamilton
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Elsevier 2010-05-01
Reeks:	Journal of Lipid Research
Onderwerpen:	caveolae caveolin-1 caveolin-3 cholesterol lipid raft transport
Online toegang:	http://www.sciencedirect.com/science/article/pii/S0022227520410466
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