Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma

Abstract Background BRAF inhibitors are widely employed in the treatment of melanoma with the BRAF V600E mutation. However, the development of resistance compromises their therapeutic efficacy. Diverse genomic and transcriptomic alterations are found in BRAF inhibitor resistant melanoma, posing a pr...

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Principais autores:	Byung-Sun Park, Heeju Jeon, Yeonseo Kim, Haejin Kwon, Ga-Eun Choi, Sung-Gil Chi, Hyun-Mee Park, Hyunbeom Lee, Tackhoon Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-07-01
Colecção:	Molecular Cancer
Assuntos:	Melanoma BRAF Vemurafenib Polyamine Hypusination c-Myc
Acesso em linha:	https://doi.org/10.1186/s12943-024-02031-w
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