Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma

Abstract Background BRAF inhibitors are widely employed in the treatment of melanoma with the BRAF V600E mutation. However, the development of resistance compromises their therapeutic efficacy. Diverse genomic and transcriptomic alterations are found in BRAF inhibitor resistant melanoma, posing a pr...

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Главные авторы:	Byung-Sun Park, Heeju Jeon, Yeonseo Kim, Haejin Kwon, Ga-Eun Choi, Sung-Gil Chi, Hyun-Mee Park, Hyunbeom Lee, Tackhoon Kim
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-07-01
Серии:	Molecular Cancer
Предметы:	Melanoma BRAF Vemurafenib Polyamine Hypusination c-Myc
Online-ссылка:	https://doi.org/10.1186/s12943-024-02031-w
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